本期文章：《科学》：Volume 381 Issue 6657

美国芝加哥大学Eugene B. Chang研究团队发现一种维持念珠菌肠道共生的潘氏细胞抗菌肽。相关论文发表在2023年8月4日出版的《科学》杂志上。

研究人员发现，YY肽（PYY1-36），而非内分泌PYY3-36，可作为肠道上皮潘氏细胞（PC）表达的抗菌肽（AMP）发挥作用。PC-PYY包装成分泌颗粒，分泌到表面粘液中并被表面粘液保留，从而优化了PC-PYY的活性。虽然PC-PYY具有一定的抗菌活性，但它对毒性白色念珠菌菌丝具有选择性抗真菌活性，而对酵母菌则没有。PC-PYY是一种阳离子分子，可与真菌菌丝的阴离子表面相互作用，导致膜破坏和转录重编程，从而选择酵母表型。因此，PC-PYY是一种抗真菌AMP，有助于维持肠道真菌共生。

据介绍，哺乳动物的肠道会分泌一系列多功能肽，这些肽会影响食欲、肠道分泌和蠕动，而其他肽则会调节微生物群。

附：英文原文

Title: Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism

Author: Joseph F. Pierre, Brian M. Peters, Diana La Torre, Ashley M. Sidebottom, Yun Tao, Xiaorong Zhu, Candace M. Cham, Ling Wang, Amal Kambal, Katharine G. Harris, Julian F. Silva, Olga Zaborina, John C. Alverdy, Herbert Herzog, Jessica Witchley, Suzanne M. Noble, Vanessa A. Leone, Eugene B. Chang

Issue&Volume: 2023-08-04

Abstract: The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility whereas others regulate the microbiota. We have found that peptide YY (PYY1-36), but not endocrine PYY3-36, acts as an antimicrobial peptide (AMP) expressed by gut epithelial paneth cells (PC). PC-PYY is packaged into secretory granules and is secreted into and retained by surface mucus, which optimizes PC-PYY activity. Although PC-PYY shows some antibacterial activity, it displays selective antifungal activity against virulent Candida albicans hyphae—but not the yeast form. PC-PYY is a cationic molecule that interacts with the anionic surfaces of fungal hyphae to cause membrane disruption and transcriptional reprogramming that selects for the yeast phenotype. Hence, PC-PYY is an antifungal AMP that contributes to the maintenance of gut fungal commensalism.

DOI: abq3178