本期文章：《科学》：Volume 381 Issue 6657

瑞士日内瓦大学Mikael J. Pittet课题组发现，CXCL9:SPP1巨噬细胞极性确定控制人类癌症的细胞程序网络。这一研究成果于2023年8月4日发表在国际学术期刊《科学》上。

考虑到微环境的变化可能揭示了支配瘤内细胞程序和疾病预后的规则，研究人员重点调查了肿瘤间的变化，即对52例头颈部鳞状细胞癌进行了研究。研究人员发现，由CXCL9和SPP1（CS）表达而非传统的M1和M2标记物定义的巨噬细胞极性与预后有明显的关联。CS巨噬细胞极性还确定了一个高度协调的促癌或抗癌变量网络，该网络涉及每种肿瘤相关细胞类型，并且在空间上是有组织的。研究人员将这些发现扩展到了其他癌症适应症。总之，这些结果表明，尽管肿瘤微环境（TME）很复杂，但它们能协调控制人类癌症的一致反应，而CS巨噬细胞极性是其中一个相关但简单的变量。

据介绍，TME会影响癌症的进展，但它很复杂，而且往往因患者而异。

附：英文原文

Title: CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers

Author: Ruben Bill, Pratyaksha Wirapati, Marius Messemaker, Whijae Roh, Beatrice Zitti, Florent Duval, Máté Kiss, Jong Chul Park, Talia M. Saal, Jan Hoelzl, David Tarussio, Fabrizio Benedetti, Stéphanie Tissot, Lana Kandalaft, Marco Varrone, Giovanni Ciriello, Thomas A. McKee, Yan Monnier, Maxime Mermod, Emily M. Blaum, Irena Gushterova, Anna L. K. Gonye, Nir Hacohen, Gad Getz, Thorsten R. Mempel, Allon M. Klein, Ralph Weissleder, William C. Faquin, Peter M. Sadow, Derrick Lin, Sara I. Pai, Moshe Sade-Feldman, Mikael J. Pittet

Issue&Volume: 2023-08-04

Abstract: Tumor microenvironments (TMEs) influence cancer progression but are complex and often differ between patients. Considering that microenvironment variations may reveal rules governing intratumoral cellular programs and disease outcome, we focused on tumor-to-tumor variation to examine 52 head and neck squamous cell carcinomas. We found that macrophage polarity—defined by CXCL9 and SPP1 (CS) expression but not by conventional M1 and M2 markers—had a noticeably strong prognostic association. CS macrophage polarity also identified a highly coordinated network of either pro- or antitumor variables, which involved each tumor-associated cell type and was spatially organized. We extended these findings to other cancer indications. Overall, these results suggest that, despite their complexity, TMEs coordinate coherent responses that control human cancers and for which CS macrophage polarity is a relevant yet simple variable.

DOI: ade2292